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Backung up Exchange 2016 and ERP results in hanging clients/users

We are using RR 6.1.0.645 on a Server 2012R2. Backung up our Exchange Server 2016 and our application server for the erp software is nearly almost runing into vss errors and the applications mail and erp cannot be used by our clients/users, beceaus it seems to freeze. So Rapid Recovery is not really working for us :-( What can I do? Anyone else got these issues?